Abstract Objective To analyze the time trend and the factors regarding the diagnosis of latestage breast cancer in Brazil from 2000 to 2012.Methods We conducted a retrospective cohort study using data from hospital-based cancer registries.Joinpoint regression was used to analyze the time trends of stage at diagnosis.The risk of late-stage presentat
Background: congenital adrenal hyperplasia is the most frequent cause of sexual ambiguity in childhood.Molecular diagnosis is an element to be considered for the management and genetic counseling of patients and relatives at risk.Objective: to identify the I172N mutation, to determine its frequency in the studied population and its possible relatio
Root-knot nematodes induce galls that contain giant-feeding cells harboring multiple enlarged nuclei within the roots of host plants.It is recognized that the cell cycle plays an essential role in the set-up of a peculiar nuclear organization that seemingly steers nematode feeding site induction and development.Functional studies of a large set of
Stochastic Bernstein (SB) approximation can tackle the problem of baseline drift correction of instrumentation data.This is demonstrated for spectral data: matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) data.Two SB schemes for removing the baseline drift are presented: iterative and direct.Following an expl
BackgroundIn the past 2 decades, many countries have recognized the use of electronic systems for disease surveillance and outbreak response as an important strategy for disease control and prevention.In low- and middle-income countries, the adoption of these electronic systems remains a priority and has attracted the support of global health playe